Application of reverse vaccinology in vaccine research and development of infectious diseases

Reverse vaceinology is a new technique in development of vaccine that makes use of the information of genome sequences and bioinformatics to identify candidate vaccines quickly.This approach has been successfully applied to the identification of meningococcus B as potential candidates,and other important human pathogens.It reveals that reverse vaccinology has wide prospect of application in the research and development of new vaccines. Key words: Reverse vaccinology; Candidate antigen; Genome