原发性血小板增多症
真性红细胞增多症
骨髓纤维化
入射(几何)
骨髓增生性疾病
流行病学
医学
肿瘤科
内科学
髓样
民族
费城染色体
人口学
遗传学
骨髓
生物
基因
物理
社会学
人类学
光学
染色体易位
作者
Rory M. Shallis,Rong Wang,Nikolai A. Podoltsev
标识
DOI:10.1016/j.hoc.2020.11.005
摘要
Polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) comprise the BCR-ABL-negative classical myeloproliferative neoplasms (MPNs). These clonal myeloid diseases are principally driven by well-described molecular events; however, factors leading to their acquisition are not well understood. Beyond increasing age, male sex, and race/ethnicity differences, few consistent risk factors for the MPNs are known. PV and ET have an incidence of 0.5 to 4.0 and 1.1 to 2.0 cases per 100,000 person-years, respectively, and predict similar survival. PMF, which has an incidence of about 0.3 to 2.0 cases per 100,000 person-years, is associated with the shortest survival of the MPNs.
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