免疫学
实验性自身免疫性脑脊髓炎
免疫系统
旁观者效应
免疫耐受
自身免疫性疾病
佐剂
T细胞
多发性硬化
抗原
效应器
生物
疾病
自身免疫
医学
抗体
病理
作者
Christina Krienke,Laura Kolb,Elif Diken,Michael Streuber,Sarah Kirchhoff,Thomas Bukur,Özlem Akilli-Öztürk,Lena M. Kranz,Hendrik Berger,Jutta Petschenka,Mustafa Diken,Sebastian Kreiter,Nir Yogev,Ari Waisman,Katalin Karikó,Özlem Türeci,Uğur Şahin
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-01-08
卷期号:371 (6525): 145-153
被引量:210
标识
DOI:10.1126/science.aay3638
摘要
Precision therapy for immune tolerance Autoimmune diseases, such as multiple sclerosis (MS), result from a breach of immunological self-tolerance and tissue damage by autoreactive T lymphocytes. Current treatments can cause systemic immune suppression and side effects such as increased risk of infections. Krienke et al. designed a messenger RNA vaccine strategy that lacks adjuvant activity and delivers MS autoantigens into lymphoid dendritic cells. This approach expands a distinct type of antigen-specific effector regulatory T cell that suppresses autoreactivity against targeted autoantigens and promotes bystander suppression of autoreactive T cells against other myelin-specific autoantigens. In mouse models of MS, the vaccine delayed the onset and reduced the severity of established disease without showing overt symptoms of general immune suppression. Science , this issue p. 145
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