This paper deals with the mechanism and control of a micromanipulator with six degrees of freedom aimed at applications in biotechnology and microsurgery. Since operations in these fields develop rapidly and are complicated, a dexterous micromanipulation system has long been desired. This paper proposes a 6 D. O. F Micromanipulator to make such work easier. The manipulator has the following features: (1) The manipulator has 6 D. O. F. The tip of this manipulator can move along three axes, and also can rotate along each axis. (2) This micromanipulator is very small and light, since it is made of PZT actuators. (3) Since it has a position and force feedback system, it can control desired poses and forces. (4) A fuzzylike variable gain feedback system is employed here, and hence the system performs better than the fixed gain feedback system. These technical merits will make it possible to operate the micromanipulator in much more complicated environments under a microscope.