The Green Revolution ushered in the 1960s brought unprecedented transformation in agricultural production, productivity, food security, and poverty reduction. But, it has now waned. The numbers of hungry, undernourished, and poor remain stubbornly high. Moreover, the natural agricultural production resources, particularly water and land, have shrunk and degraded. The problem has further exacerbated by the global climate change and extreme weather fluctuations widely depressing agricultural yields, increasing production instability, and degrading natural resources. If the change is not managed adequately, the agricultural yields will drop by up to 20% by the year 2050 and the national GDP will erode annually at least by 1%. A series of adaptation and mitigation pathways involving business unusual have been suggested toward developing climate smart agriculture by increasing agricultural resilience to climate change through integrating technology, policy, investment, and institutions with special reference to the resource poor, women, and other more vulnerable people.