Influence of Environment Factors and DNA Methylation on Lung Tumorigenesis

Lung cancer is the leading cause of tumor-related death,its incidence and mortality are both ahead of the disease spectrum.Cigarette smoking was identified as the single most predominant cause of the lung cancer epidemic,but the other factors were found,including radioactive substances,asbestos,metal and nutrition factors.Aberrant DNA methylation effects in lung cancer illustrates the mechanism by which environmental factors may interact with key genes involved in tumour suppression and contribute the way how to influence lung cancer.With the continuous investigate on the mechanism of lung tumorigenesis,aberrant DNA methylation induced by environment factors will be a potential useful biomarker to diagnosis or prognosis of the disease.Some special gene methylation is closely related with lung cancer,and as an early common event in the tumorigenesis,it is very important to the early diagnosis of lung tumor.