蔷薇花
代谢综合征
肠道菌群
微生物群
生物
基因组
拟杆菌
胰岛素抵抗
肥胖
内科学
生理学
内分泌学
生物信息学
医学
遗传学
细菌
生物化学
基因
作者
Qian Qin,Yan Su,Yang Yang,Jingfeng Chen,Tiantian Li,Xinxin Gao,Hang Yan,Youxiang Wang,Jiao Wang,Shoujun Wang,Shuzhe Ding
标识
DOI:10.3389/fmicb.2021.682721
摘要
Metabolic syndrome (MetS) is a wide-ranging disorder, which includes insulin resistance, altered glucose and lipid metabolism, and increased blood pressure and visceral obesity. MetS symptoms combine to result in a significant increase in cardiovascular risk. It is therefore critical to treat MetS in the early stages of the disorder. In this study, 123 MetS patients and 304 controls were recruited to determine whether the gut microbiome plays a role in MetS development and progression. By using whole-genome shotgun sequencing, we found that the gut microbiomes of MetS patients were different from those of controls, with MetS patients possessing significantly lower gut microbiome diversity. In addition, 28 bacterial species were negatively correlated with waist circumstance, with Alistipes onderdonkii showing the strongest correlation, followed by Bacteroides thetaiotaomicron , Clostridium asparagiforme , Clostridium citroniae , Clostridium scindens , and Roseburia intestinalis . These species were also enriched in controls relative to MetS patients. In addition, pathways involved in the biosynthesis of carbohydrates, fatty acids, and lipids were enriched in the MetS group, indicating that microbial functions related to fermentation may play a role in MetS. We also found that microbiome changes in MetS patients may aggravate inflammation and contribute to MetS diseases by inhibiting the production of short-chain fatty acids (SCFAs). Taken together, these results indicate the potential utility of beneficial gut microbiota as a potential therapeutic to alleviate MetS.
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