脂肪变性
医学
肠道菌群
脂肪肝
脂质代谢
内科学
胆汁酸
瞬态弹性成像
内分泌学
餐食
代谢综合征
非酒精性脂肪肝
肝硬化
肥胖
免疫学
疾病
肝纤维化
作者
Anja Figge,Svenja Sydor,C Wenning,Paul Manka,S Aßmuth,Ramiro Vílchez-Vargas,Alexander Link,Andreas Jähnert,Susanne Brodesser,Christina Lucas,Yulia A. Nevzorova,Klaas Nico Faber,Han Moshage,Mustafa Porsch-Özçürümez,Guido Gerken,Francisco Javier Cubero,Ali Canbay,Lars P. Bechmann
标识
DOI:10.1016/j.clnu.2021.04.008
摘要
Background & aims Regular consumption of fast-food (FF) as a form of typical Western style diet is associated with obesity and the metabolic syndrome, including its hepatic manifestation nonalcoholic fatty liver disease. Currently, it remains unclear how intermittent excess FF consumption may influence liver metabolism. The study aimed to characterize the effects of a single FF binge on hepatic steatosis, inflammation, bile acid (BA), glucose and lipid metabolism. Methods Twenty-five healthy individuals received a FF meal and were asked to continue eating either for a two-hour period or until fully saturated. Serum levels of transaminases, fasting BA, lipid profile, glucose and cytokine levels as well as transient elastography and controlled attenuation parameter (CAP; to assess hepatic steatosis) were analyzed before (day 0) and the day after FF binge (day 1). Feces was collected prior and after the FF challenge for microbiota analysis. Results The FF meal induced a modest increase in CAP, which was accompanied by a robust increase of fasting serum BA levels. Surprisingly, levels of cholesterol and bilirubin were significantly lower after the FF meal. Differentiating individuals with a relevant delta BA (>1 μmol/l) increase vs. individuals without (delta BA ≤1 μmol/l), identified several gut microbiota, as well as gender to be associated with the BA increase and the observed alterations in liver function, metabolism and inflammation. Conclusion A single binge FF meal leads to a robust increase in serum BA levels and alterations in parameters of liver injury and metabolism, indicating a novel metabolic aspect of the gut–liver axis.
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