Mineral weathering relative to soil has two parts: weathering happened previously where hard rocks have been broken down into clay which ultimately forms soil, loams, and unconsolidated sands both chemically and physically and other is soil and mineral weathering happening currently which acts as vital source of crop nutrients. This chapter discusses background of chemical weathering of minerals, sequence of weathering of minerals from soil, mainly throwing light on the factors which controls the rate of chemical weathering like temperature and time factor, biotic process, oxidation, reduction, water, leaching, acidity, and many more.