Igniting Endogenous Calcipoptosis via ER‐Mitochondrial Calcium Shuttle Hijacking for Potent Antitumor Immunity

dysregulation polarizes macrophages into a pro-inflammatory phenotype and stiffens cancer cells to establish biochemical and mechanical immunosurveillance. The nanoagonist demonstrated potent ablation of primary tumors and suppression of metastatic growth in breast and liver cancer models. Overall, this work enables customizable subcellular bioenergetic disruption without systemic toxicity risks, which pioneers a translatable strategy that redefines the frontier of calcium-based immunotherapy.