生物
互补DNA
基因
遗传学
序列(生物学)
DNA
基因表达
分子生物学
DNA测序
计算生物学
作者
Anna Corradi,Laura Croci,Carol L. Stayton,Massimo Gulisano,Edoardo Boncinelli,G. Giacomo Consalez
出处
期刊:Genomics
[Elsevier]
日期:1996-09-01
卷期号:36 (2): 288-295
被引量:17
标识
DOI:10.1006/geno.1996.0464
摘要
DNA mismatch repair genes (MMR) have been actively studied in humans for their role in cancer susceptibility. Recently, GTBP, a new member of the MMR gene family, has been cloned and found to encode a 160-kDa protein that forms a heterodimer with hMSH2. Our group has isolated and characterized the mouse homolog of GTBP. The transcript, termed Gtmbp (G/T mismatch-binding protein), encodes a protein highly similar to its human counterpart. The gene is markedly conserved across species and maps to the distal portion of mouse chromosome 17, in a region homologous to human 2p. One Gtmbp-related sequence maps to proximal mouse chromosome 4. Studies of the expression of Gtmbp suggest that its regulated transcription is tightly linked to the level of DNA replication, consistent with the protein's DNA proofreading function.
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