Now days the research work in the drug development is mainly focusing on targeted drug delivery for better therapeutic effect. Various carriers for delivering the drug have been reported, among these erythrocytes (RBC) constitute potential biocompatible carriers since they possess several properties which make them unique and useful carriers. Erythrocytes are biocompatible, biodegradable, possess long circulation half-lives, and can be loaded with a variety of biologically active compounds using various chemical and physical methods.