交叉研究
医学
安慰剂
血压
维生素
谷胱甘肽过氧化物酶
维生素C
维生素E
内科学
微量营养素
抗氧化剂
内分泌学
生理学
氧化应激
化学
生物化学
病理
超氧化物歧化酶
替代医学
作者
Jingyi Ren,Jufeng Liang,Jiaqi Wang,Bowen Yin,Fan Zhang,Xiang Li,Siqi Zhu,Hua Tian,Qiqi Cui,Ji‐Hyun Song,Gang Liu,Wen Hua Ling,Yun‐Bao Ma
标识
DOI:10.1016/j.ecoenv.2022.113735
摘要
Evidence on the health benefits of vitamin C supplementation in highly polluted areas has not been evaluated. We aimed to evaluate whether dietary vitamin C supplementation can improve vascular health linked to particulate matter (PM) exposure. A randomised double-blind crossover trial involving 58 health young adults was performed in Shijiazhuang, China in 2018. All subjects were randomly assigned to the vitamin C supplementation group (2000 mg/d) or placebo group for a week alternating with a 2 week washout period. Fifteen circulating biomarkers were measured. Linear mixed-effect model was applied to evaluate the effect of vitamin C supplementation on health outcomes. The average concentrations of PM2.5 and PM10 were 164.91 and 327.05 μg/m3, respectively. Vitamin C supplementation was significantly associated with a 19.47% decrease in interleukin-6 (IL-6), 17.30% decrease in tumour necrosis factor-a (TNF-α), 34.01% decrease in C-reactive protein (CRP), 3.37% decrease in systolic blood pressure (SBP) and 6.03% decrease in pulse pressure (PP). Furthermore, glutathione peroxidase (GSH-Px) was significantly increased by 7.15%. Sex-subgroup analysis showed that vitamin C significantly reduced TNF-α by 27.85% in male participants and significantly increased APOB by 6.28% and GSH-Px by 14.47% only in female participants. This study indicated that vitamin C supplementation may protect vascular vessels against PM exposure among healthy young adults in China.
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