磁共振弥散成像
帕金森病
无线电技术
医学
疾病
磁共振成像
放射科
病理
作者
Jingwen Li,Xiaoming Liu,Xinyi Wang,Hanshu Liu,Zhicheng Lin,Nian Xiong
出处
期刊:Brain Sciences
[MDPI AG]
日期:2022-06-29
卷期号:12 (7): 851-851
被引量:3
标识
DOI:10.3390/brainsci12070851
摘要
Diagnosis of Parkinson's Disease (PD) based on clinical symptoms and scale scores is mostly objective, and the accuracy of neuroimaging for PD diagnosis remains controversial. This study aims to introduce a radiomic tool to improve the sensitivity and specificity of diagnosis based on Diffusion Tensor Imaging (DTI) metrics.In this machine learning-based retrospective study, we collected basic clinical information and DTI images from 54 healthy controls (HCs) and 56 PD patients. Among them, 60 subjects (30 PD patients and 30 HCs) were assigned to the training group, whereas the test cohort was 26 PD patients and 24 HCs. After the feature extraction and selection using newly developed image processing software Ray-plus, LASSO regression was used to finalize radiomic features.A total of 4600 radiomic features were extracted, of which 12 were finally selected. The values of the AUC (area under the subject operating curve) in the training group, the validation group, and overall were 0.911, 0.931, and 0.919, respectively.This study introduced a novel radiometric and computer algorithm based on DTI images, which can help increase the sensitivity and specificity of PD screening.
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