Genetic variants associated with longitudinal changes in brain structure across the lifespan

脑形态计量学神经科学大脑大小大脑结构与功能精神分裂症（面向对象编程）生物失调家庭人脑全基因组关联研究神经影像学心理学基因磁共振成像遗传学医学基因型单核苷酸多态性精神科放射科

作者

Rachel M. Brouwer,Marieke Klein,Katrina L. Grasby,Hugo G. Schnack,Neda Jahanshad,Jalmar Teeuw,Sophia I. Thomopoulos,Emma Sprooten,Carol E. Franz,Nitin Gogtay,William S. Kremen,Matthew S. Panizzon,Loes Olde Loohuis,Christopher D. Whelan,Moji Aghajani,Clara Alloza,Dag Alnæs,Éric Artiges,Rosa Ayesa-Arriola,Gareth J. Barker,Mark E. Bastin,Elisabet Blok,Erlend Bøen,Isabella A. Breukelaar,Joanna K. Bright,Elizabeth E.L. Buimer,Robin Bülow,Dara M. Cannon,Simone Ciufolini,Nicolás Crossley,Christienne G. Damatac,Paola Dazzan,Casper L. de Mol,Sonja M C de Zwarte,Sylvane Desrivières,Covadonga M. Díaz‐Caneja,Nhat Trung Doan,Katharina Dohm,Juliane H. Fröhner,Janik Goltermann,Antoine Grigis,Dominik Grotegerd,Laura K.M. Han,Mathew A. Harris,Catharina A. Hartman,Sarah J. Heany,Walter Heindel,Dirk J. Heslenfeld,Sarah Hohmann,Bernd Ittermann,Philip R. Jansen,Joost Janssen,Tianye Jia,Jiyang Jiang,Christiane Jockwitz,Temmuz Karali,Daniel Keeser,Martijn G.J.C. Koevoets,Rhoshel Lenroot,Berend Malchow,René C.W. Mandl,Vicente Medel,Susanne Meinert,Catherine A. Morgan,Thomas W. Mühleisen,Leila Nabulsi,Nils Opel,Víctor Ortiz‐García de la Foz,Bronwyn Overs,Marie‐Laure Paillère Martinot,Ronny Redlich,Tiago Reis Marques,Jonathan Repple,Gloria Roberts,Gennady V. Roshchupkin,Nikita Setiaman,Elena Shumskaya,Frederike Stein,Gustavo Sudre,Shun Takahashi,Anbupalam Thalamuthu,Diana Tordesillas‐Gutiérrez,Aad van der Lugt,Neeltje E.M. van Haren,Joanna M. Wardlaw,Wen Wang,Henk‐Jan Westeneng,Katharina Wittfeld,Alyssa H. Zhu,André Zugman,Nicola J. Armstrong,Gaia Bonfiglio,Janita Bralten,Shareefa Dalvie,Gail Davies,Marta Di Forti,Linda Ding,Gary Donohoe,Andreas J. Forstner,Javier González-Peñas,Joao Guimaraes,Georg Homuth,Jouke Jan Hottenga,Maria J. Knol,John B. Kwok,Stéphanie Le Hellard,Karen A. Mather,Yuri Milaneschi,Derek W. Morris,Markus M. Nöthen,Sergi Papiol,Marcella Rietschel,Marcos Santoro,Vidar M. Steen,Jason L. Stein,Fabian Streit,Rick M. Tankard,Alexander Teumer,Dennis van ‘t Ent,Dennis van der Meer,Kristel R. van Eijk,Evangelos Vassos,Javier Vázquez-Bourgon,Stephanie H. Witt,Hieab H.H. Adams,Ingrid Agartz,David Ames,Katrin Amunts,Ole A. Andreassen,Celso Arango,Tobias Banaschewski,Bernhard T. Baune,Síntia Belangero,Arun L.W. Bokde,Dorret I. Boomsma,Rodrigo Bressan,Henry Brodaty,Jan K. Buitelaar,Wiepke Cahn,Svenja Caspers,Sven Cichon,Benedicto Crespo‐Facorro,Simon R. Cox,Udo Dannlowski,Torbjørn Elvsåshagen,Thomas Espeseth,Peter Falkai,Simon E. Fisher,Herta Flor,Janice M. Fullerton,Hugh Garavan,Penny A. Gowland,Hans‐Jörgen Grabe,Tim Hahn,Andreas Heinz,Manon H. J. Hillegers,Jacqueline Hoare,Pieter J. Hoekstra,M. Arfan Ikram,Andrea Parolin Jackowski,Andreas Jansen,Erik G. Jönsson,René S. Kahn,Tilo Kircher,Mayuresh S. Korgaonkar,Axel Krug,Hervé Lemaítre,Ulrik Fredrik Malt,Jean‐Luc Martinot,Colm McDonald,Philip B. Mitchell,Ryan L. Muetzel,Robin M. Murray,Frauke Nees,Igor Nenadić,Jaap Oosterlaan,Roel A. Ophoff,Pedro Mário Pan,Brenda W. J. H. Penninx,Luise Poustka,Perminder S. Sachdev,Giovanni Abrahão Salum,Peter R. Schofield,Günter Schumann,Philip Shaw,Kang Sim,Michael N. Smolka,Dan J. Stein,Julian N. Trollor,Leonard H van den Berg,Jan H. Veldink,Henrik Walter,Lars T. Westlye,Robert Whelan,Tonya White,Margaret J. Wright,Sarah E. Medland,Barbara Franke,Paul M. Thompson,Hilleke E. Hulshoff Pol

出处

期刊：Nature Neuroscience [Springer Nature]
日期：2022-04-01 卷期号：25 (4): 421-432 被引量：78

标识

DOI：10.1038/s41593-022-01042-4

摘要

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.

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Genetic variants associated with longitudinal changes in brain structure across the lifespan

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