无症状的
抗体
医学
免疫学
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
2019年冠状病毒病(COVID-19)
体液免疫
免疫
血清学
内科学
聚合酶链反应
病毒学
作者
Mehmet Sami Islamoglu,Mahir Cengiz,Betul Borku Uysal,Hande Ikitimur,Zeynep Ozdemir,Ahsen Karamehmetoglu,Ayşe Ezgi Akbulut,Ayşe Nur Bakdur,Azize Ozdemir,Habibe Kayıkcıoglu,Hatice Ozdemir,Rumeysa Uces,Sema Ersoy,Serap Yavuzer
摘要
In this period when mutant strains are increasing all over the world, studies on how much humoral immunity will protect against the Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) are quite limited. The aim of our study is to investigate the positivity and antibody levels of the COVID-19 reverse transcription polymerase chain reaction (RT-PCR) test, the frequency of SARS-CoV-2 re-infection, and the protective antibody level against re-infection.Patients who were positive for COVID-19 IgG antibody between 1 July and 31 August were included in our study. The COVID-19 RT-PCR test positivity, age, gender and comorbidities of these patients were recorded before this date. The COVID-19 RT-PCR test positivity of these patients was followed from the National COVID-19 Database between September 1, 2020 and February 28, 2021.1665 patients (female: male 683: 982, mean age 40.6±13.4 years). Among all patients, 14 patients had reinfection and the frequency of reinfection was 0.8%. It was observed that the frequency of reinfection was more frequent in patients with PCR negative (p<0.001). The IgG cut-off value causing reinfection was found to be 11.9 (AUC: 0.844, 79.2% sensitivity, 78.6% specificity) (p<0.001).Humoral antibodies against SARS-CoV-2 were protective against COVID-19 reinfection, 0.8% of the patients had reinfection and the resultant reinfection was mostly seen in PCR negative patients who were asymptomatic.
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