医学
儿科
脑病
2019年冠状病毒病(COVID-19)
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
大流行
疾病
病理生理学
冠状病毒
内科学
传染病(医学专业)
作者
Sibel Laçinel Gürlevik,Ceren Günbey,Yasemin Özsürekçi,Pembe Derin Oygar,Selman Kesici,Rahşan Göçmen,Orkun Aydın,Çağrı Mesut Temuçin,Erennur Tufan,Kıvanc Terzi,Demet Baltu,Tuğba Öztürk,Özlem Tekşam,Seza Özen,Kader Karlı Oğuz,Ali Bülent Cengiz,Dilek Yalnızoğlu
标识
DOI:10.1016/j.ejpn.2022.02.003
摘要
Since December 2019, coronavirus disease 2019 (COVID-19) has become a global pandemic caused by highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although respiratory disease and multisystem inflammatory syndrome in children (MIS-C) are main clinical presentations in children, numerous neurological manifestations are being described increasingly. We aimed to investigate new onset neurological symptoms associated with SARS-CoV-2 in pediatric patients in order to establish a possible relationship as well as to understand the underlying pathophysiological mechanisms between SARS-CoV-2 infection and neurological findings.We analyzed retrospectively children who had neurologic manifestations temporally associated with SARS-CoV-2 infection at Hacettepe University İhsan Doğramaci Children's Hospital. We performed a literature search between March 20, 2020 and March 30, 2021. Articles that report children with COVID-19 related neurological manifestations were included.We have observed 15 consecutive cases with new onset neurological manifestations along with confirmed SARS-CoV-2 infection. Age at hospitalization ranged from three months to 17 years. Ten patients had central nervous system involvement, and most common manifestation was encephalopathy (5/10), which is also one of the most common manifestations of the patients mentioned in the relevant 39 articles we reviewed.Children with COVID-19 can present with neurologic findings such as encephalopathy, seizures, cerebrovascular events as well as abnormal eye movements. Clinical suspicion and awareness are required to show the association between neurologic manifestations and COVID-19.
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