立体中心
烯丙基重排
铱
对映选择合成
炔烃
化学
催化作用
立体化学
三键
药物化学
双键
有机化学
作者
Zixuan Wang,Pengchao Gao,E Lin,Bi‐Jie Li
标识
DOI:10.1002/ange.202200075
摘要
Abstract Preparation of skipped dienes with a quaternary carbon center at the C‐3 position remains a synthetic challenge. We report here an iridium‐catalyzed formal addition of tertiary sp 3 C−H bond to alkyne for the facile preparation of skipped dienes. The tertiary allylic C−H bond is cleaved regioselectively, at the site of which a new C−C bond is formed. Enantioselective construction of acyclic quaternary carbon stereocenters is also demonstrated.
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