非翻译区
三素数非翻译区
系统性红斑狼疮
生物
基因
肿瘤坏死因子α
阿尔法(金融)
遗传学
分子生物学
免疫学
信使核糖核酸
疾病
医学
病理
护理部
患者满意度
结构效度
作者
Chaim O. Jacob,S K Lee,Gideon Strassmann
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:1996-04-15
卷期号:156 (8): 3043-3050
被引量:79
标识
DOI:10.4049/jimmunol.156.8.3043
摘要
Lupus-prone mice show reduced production of TNF-alpha and, upon long-term treatment with recombinant TNF-alpha, significant protection from disease development. Mutational analysis of the 5'-untranslated region (UTR) and 3'-UTR of the mouse TNF-alpha gene reveals a marked degree of polymorphism. Transient expression experiments in the RAW 264.7 macrophage-like cell line using the luciferase reporter system suggest an important role for the mutations in the 3'-UTR in the biosynthesis of TNF-alpha, and provide a molecular explanation for the reduced TNF-alpha production in lupus-prone NZW mice.
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