洁净室
赫帕
污染
环境科学
空气过滤器
废物管理
污染控制
制浆造纸工业
滤波器(信号处理)
材料科学
机械工程
纳米技术
计算机科学
工程类
生物
生态学
计算机视觉
入口
作者
Bengt Ljungqvist,Berit Reinmüller
出处
期刊:PubMed
日期:2007-03-30
卷期号:61 (1): 44-50
摘要
In pharmaceutical manufacturing, freeze-drying processes can be adversely affected by temperature differences relative to the surrounding air. Loading and unloading of freeze-dryers are performed either without or with temperature differences between the cleanroom and the chamber of the freeze-dryer. This operation can cause a flow of room air through the opening, creating a contamination risk, especially when manual handling of material is performed in this area. To minimize this risk, a high-efficiency particulate air (HEPA) filter unit should be installed above the opening to provide clean air and protect the opening. Here the theoretical relationships are discussed and design criteria are presented.
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