软骨
再生(生物学)
自愈水凝胶
再生医学
组织工程
骨关节炎
关节软骨
关节软骨损伤
医学
生物医学工程
生物
解剖
病理
材料科学
细胞生物学
干细胞
替代医学
高分子化学
作者
Chuntie Zhu,Qiong Wu,Feiyu Wang,Xu Zhang,Fubo Chen,Xiyang Liu,Qixiang Yang,Lei Zhu
出处
期刊:Current stem cell research & therapy
[Bentham Science]
日期:2018-08-29
卷期号:13 (7): 517-525
被引量:7
标识
DOI:10.2174/1574888x13666180514123103
摘要
Local cartilage or osteochondral lesions are painful and harmful. Besides pain and limited function of joints, cartilage defect is considered as one of the leading extrinsic risk factors for osteoarthritis (OA). Thus, clinicians and scientists have paid great attention to regenerative therapeutic methods for the early treatment of cartilaginous defects. Regenerative medicine, showing great hope for regenerating cartilage tissue, relies on the combination of biodegradable scaffolds and particular biological factors, such as growth factors, genetic cues. Among all biomaterials, hydrogels have become a promising type of scaffolds for simultaneous cell growth and drug delivery in cartilage tissue engineering. A wide range of animal models have been applied in testing repair with hydrogels in cartilage defects. This review summarized the current animal models used to test hydrogels technologies for the regeneration of cartilage. Advantages and disadvantages in the establishment of the cartilage defect animal models among different species were emphasized, as well as the feasibility of replication of diseases in animals.
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