共晶
溶解度
溶解
溶剂
化学
化学工程
材料科学
差示扫描量热法
有机化学
核化学
热力学
分子
氢键
物理
工程类
作者
Zhengzheng Zhou,Wanying Li,Wei-Jhe Sun,Tong‐Bu Lu,Henry H.Y. Tong,Changquan Calvin Sun,Ying Zheng
标识
DOI:10.1016/j.ijpharm.2016.06.006
摘要
Two new 1:1 cocrystals of resveratrol (RES) with 4-aminobenzamide (RES-4ABZ) and isoniazid (RES-ISN) were synthesized by liquid assisted grinding (LAG) and rapid solvent removal (RSR) methods using ethanol as solvent. Their physiochemical properties were characterized using PXRD, DSC, solid state and solution NMR, FT-IR, and HPLC. Pharmaceutically relevant properties, including tabletability, solubility, intrinsic dissolution rate, and hygroscopicity, were evaluated. Temperature-composition phase diagram for RES-ISN cocrystal system was constructed from DSC data. Both cocrystals show higher solubility than resveratrol over a broad range of pH. They are phase stable and non-hygroscopic even under high humidity conditions. Importantly, both cocrystals exhibit improved solubility and tabletability compared with RES, which make them more suitable candidates for tablet formulation development.
科研通智能强力驱动
Strongly Powered by AbleSci AI