Ten-day empirical sequential or concomitant therapy is more effective than triple therapy for Helicobacter pylori eradication: A multicenter, prospective study.
阿莫西林
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质子抑制剂泵
作者
Jun-Won Chung,Jae Pil Han,Kyoung Oh Kim,Su Young Kim,Su Jin Hong,Tae Ho Kim,Chang Whan Kim,Joon Sung Kim,Byung-Wook Kim,Byoung Wook Bang,Hyung Gil Kim,Sung-Cheol Yun
Abstract Background The resistance of Helicobacter pylori to antibiotics has increased the need for new empirical, first-line treatments. However, the efficacy of sequential therapy (ST) and concomitant therapy (CT) compared with triple therapy (TT) has not been adequately evaluated. Aim In this study, we evaluated the efficacy of these empirical three regimens. Methods The 517 patients enrolled in the study were prospectively randomized to receive 10 days of TT ( n = 171), ST ( n = 170), and CT ( n = 176) at 5 university-affiliated hospitals from May 2013 to March 2015. The post-treatment H. pylori status was determined using the 13 C-urea breath test. Results The baseline characteristics were similar among the three groups. The intention-to-treat eradication rates were 62.6%, 70.6%, and 77.8% in the TT, ST, and CT groups, respectively ( p p Conclusion A higher eradication rate was achieved with empirical 10-day ST, and CT than with the TT regimen, with similar rates of compliance and treatment side effects.