Study on the pharmacokinetics of ginkgolides in 10 volunteers

OBJECTIVE To study the pharmacokinetics of ginkg ol ide A(GA) and ginkgolide B (GB).METHODS The Ginkgo biloba extract(GBE) injection was administered by intravenous infusion in 10 volunte ers and GC-MS was used to determine the concentrations of GA and GB in plasma. RESULTS The dispositions of both GA and GB were conformed to two-compartment model.t 1/2 of GA and GB were 3.73 h and 4.25 h,respe ctively.The AUC of GA and GB were 68 305.10 ng·min·mL -1 and 19 714.6 9 ng·min·mL -1 respectively.CONCLUSION The GC-MS ass ay was sensitive for the determination of GA and GB in human blood.The pharmacok inetic parameters of GA and GB from 10 volunteers were similar to those reported .