Mutation of c-MET gene in hepatic cancer

Objective AIM To investigate the mutation of c-MET gene in hepatic cancer.Methods 37 specimens of hepatic cancers were screened for mutation by PCR-SSCP and DNA sequence.Results 7 cases of hepatic cancer were screened to have mutation,Direct DNA sequence analysis showed synonymous mutations in two patients and at two-base sequence change(ACT—ATTin exon 17,ATG-ATAin exon 19).Conclusion c-MET gene may take part in the development of hepatic cancer.