Objective To explore the differences of red cell distribution width(RDW)among patients with anemia of chronic systemic disease involving hepatic anemia,renal anemia and diabetic anemia,and to determine the diagnosis value of RDW.Methods RDW values of 45 hepatic anemia,45 renal anemia and 55 diabetic anemia patients were measured by Sysmex SF-3000 hemocyte analyzer and were compared with each other.45 healthy examiners were used as normal controls.Results The RDW values of hepatic anemia and renal anemia patients were obviously higher than those of normal controls(P0.01,P0.05 respectively),but the RDW values of diabetic anemia patients had not significant difference with those of normal controls(P0.05).No significant differences could be found in the RDW values between male and female patients with the three different kinds of anemia(P0.05).The RDW values of patients with mild hepatic anemia or diabetic anemia were significantly lower than those of the patients with moderate and severe patients(P0.01,P0.05).Conclusion Detection of RDW value appeared a certain reference value to clinically identify the three different types of anemia of chronic systemic disease.For the patients with moderate diabetic anemia or above,RDW value determination was clinically significant.