Application value of fetal nuchal translucency thickness in diagnosis of chromosomal abnormality

Objective:To explore the relationship between nuchal translucency thickness(NT) thickening and fetal chromosomal abnormality.Methods:From February 2009 to January 2012,312 pregnant women with NT thickening who received prenatal examination in the hospital received fetal karyotype analysis.Results:Among 312 pregnant women with NT thickening,14 fetuses were found with chromosomal abnormality,the proportion was 4.49%,and the sensitivity and specificity of NT≥3.0 mm for diagnosis of chromosomal abnormality was 96.45% and 94.45%,respectively.Conclusion:NT thickening has important significance for early screening of chromosomal abnormality,NT≥3.0 mm is an important index for chromosomal screening.