Effect of compatibility of Coptis chinensis Franch and Evodia rutaecarpa (Juss) Benth on heat tolerance

Objective To observe the effect of compatibility in Coptis chinensis Franch and Evodia rutaecarpa(Juss) Benth(6∶1,2∶1,1∶1,1∶6) on anus temperature,survival time,and mortality in thermal environment in rats and the difference in enhancing the heat tolerance.Methods SD rats were randomly divided into 6 groups:the blank group was treated with saline water,the positive control group with the agastache rugosaq healthy water,while the experimental group C,D,E,and F with various compatibility proportions of extracts in Coptis chinensis Franch and Evodia rutaecarpa(Juss) Benth.Then the rats were exposed to heat at 41℃ in a heat chamber with relative humidity of 70% till death.The rectal temperature was measured before and 1 h after the heat exposure,and the time when death occurred were recorded.Results Compared with the blank group,group B,C,D,E and F had lower rectal temperature and prolonged survival time with decreased mortality.Group D had better action than the others.Conclusion Coptis chinensis Franch and Evodia rutaecarpa(Juss) Benth(2∶1) can significantly enhance the thermal environment of tolerance,which has the most obvious heat resistant function.