自愈水凝胶
再生(生物学)
组织工程
纳米技术
计算机科学
生化工程
设计要素和原则
人口
材料科学
生物医学工程
生物
工程类
细胞生物学
医学
软件工程
高分子化学
环境卫生
作者
Chaoming Xie,Jun Xu,Xin‐Yi Wang,San Ping Jiang,Zheng Yang,Zexin Liu,Zhuo Jiang,Zhanrong Jia,Xiong Li
标识
DOI:10.1002/mabi.202300339
摘要
Abstract The rapid growth in the portion of the aging population has led to a consequent increase in demand for biomedical hydrogels, together with an assortment of challenges that need to be overcome in this field. Smart hydrogels can autonomously sense and respond to the physiological/pathological changes of the tissue microenvironment and continuously adapt the response according to the dynamic spatiotemporal shifts in conditions. This along with other favorable properties, make smart hydrogels excellent materials for employing toward improving the precision of treatment for age‐related diseases. The key factor during the smart hydrogel design is on accurately identifying the characteristics of natural tissues and faithfully replicating the composition, structure, and biological functions of these tissues at the molecular level. Such hydrogels can accurately sense distinct physiological and external factors such as temperature and biologically active molecules, so they may in turn actively and promptly adjust their response, by regulating their own biological effects, thereby promoting damaged tissue repair. This review summarizes the design strategies employed in the creation of smart hydrogels, their response mechanisms, as well as their applications in field of tissue engineering; and concludes by briefly discussing the relevant challenges and future prospects.
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