Focused Ultrasound Ablation of the Globus Pallidus Internus for Parkinson’s Disease

One of the challenges in the management of advanced Parkinson's disease is the occurrence of motor fluctuations and dyskinesias in response to antiparkinsonian medications. The often unpredictable deterioration of motor function in the off-medication state and dyskinesias in the on-medication state can render patients disabled for many hours each day. Deep-brain stimulation of the subthalamic nucleus or the globus pallidus internus is an established treatment for patients with these complications.1 However, not all patients are eligible for deep-brain stimulation owing to coexisting conditions, and some are unwilling to consider this treatment because it involves invasive placement of electrodes in the . . .