体外成熟
卵母细胞
窦卵泡
多囊卵巢
保持生育能力
临床实习
医学
辅助生殖技术
生育率
生物
妇科
怀孕
不育
内科学
人口
卵巢
家庭医学
胚胎
胰岛素抵抗
遗传学
胰岛素
环境卫生
作者
Robert B. Gilchrist,Johan Smitz
标识
DOI:10.1016/j.fertnstert.2023.02.010
摘要
Oocyte in vitro maturation (IVM) is an assisted reproductive technology with a long and sometimes checked history. It is a minimally invasive technique involving the deliberate collection of immature oocytes from patients that have received no or minimal ovarian stimulation and the culture of oocytes to maturity in vitro, before standard procedures thereafter. Now, IVM is classified as nonexperimental and is primarily indicated for patients with a high antral follicle count, especially patients with polycystic ovaries or polycystic ovary syndrome, as well as for fertility preservation in cancer patients. In the recent past, IVM practice has had a confusing array of clinical protocols and has been slow to adapt to new scientific insights; however, recently, significant advances have been made in IVM culture methods based on new knowledge from animal studies, combined with defining a simple patient treatment protocol. These improvements have led to significant recent progress in IVM practice to the extent that IVM is now routinely practiced in a growing number of centers with specialized expertise around the world.
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