Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging

Our studies identify a novel role for epidermal Pgc-1α in controlling epidermal repair via its regulation of cellular NAD⁺ and downstream effects on p53-driven growth arrest. We also establish that parallel mechanisms are evident in aged epidermis, showing that NAD⁺ signaling is an important controller of physiologic skin repair and that dysfunction of this pathway contributes to age-related wound repair defects.