化学
丙烯酰胺
壳聚糖
马来酸
复合数
高分子化学
化学工程
聚合物
有机化学
共聚物
材料科学
复合材料
工程类
作者
Birnur Akkaya,Recep Akkaya,Sümeyye Idil CELIKKAYA,Nurgül SARIAYDIN,Kayode Yomi Raheem
标识
DOI:10.1016/j.molstruc.2022.134536
摘要
• Chitosan/poly(acrylamide-co-maleic acid) >It loaded by high efficiency> pH-sensitive • doxorubicin release A pH responsive superadsorbent composite hydrogel, chitosan-poly(acrylamide-maleic acid)(Ch-p(Ac-Ma)), were synthesized, characterized and loaded by Doxorubucin (Dox), anti-cancer drug. Chitosan solution was modified by blending biocompatible chitosan and poly(acrylamide-co-maleic acid) in the polymerization medium. This new composite hydrogel had a high loading capacity for Dox (∼90%). Some chemical characteristics of the prepared composite hydrogel were investigated by swelling test, SEM, FTIR, XRD. The drug release study confirmed the pH-responsive delivery of doxorubucin. The composite hydrogel was loaded by high efficiency and the release experiments exhibited that Dox is released more at pH 4.5 compared with pH 7.4 at 37 °C. The biocompatibility of the prepared composite hydrogel was demonstrated via XTT assay in MCF-7 cells. The Dox loaded composite showed a controlled release, especially at acidic region. The Ch-p(Ac-Ma) exhibited a good biocompatibility against breast cancer cells (MCF 7) and dose dependent drug delivery behaviour. Also, we employed molecular docking and density functional theory analysis to investigate the inhibitory activity, reactivity, and stability of Doxorubucin and target protein HER2 ((Pdb ID: 7JXH ). The interaction between Doxorubucin and target protein HER2 ((Pdb ID: 7JXH ) was investigated in the light of Molecular Docking calculations.
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