间充质干细胞
生物
平衡
再生(生物学)
免疫系统
细胞生物学
免疫学
间质细胞
间充质干细胞的临床应用
干细胞
体外
成体干细胞
癌症研究
内皮干细胞
遗传学
作者
Ying Wang,Jiankai Fang,Benming Liu,Changshun Shao,Yufang Shi
出处
期刊:Cell Stem Cell
[Elsevier]
日期:2022-11-01
卷期号:29 (11): 1515-1530
被引量:66
标识
DOI:10.1016/j.stem.2022.10.001
摘要
Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for autoimmune diseases, organ failures, and many other chronic disorders. Remarkably, the reparative and homeostatic maintenance functions of MSCs rely on their interaction with the inflammatory microenvironment. Here, we discuss the characteristics and functions of MSCs under different pathophysiological conditions and highlight how the immunomodulatory functions of MSCs are altered in accordance with the inflammatory cues. We hope to provide new insights into the diverse immunoregulatory properties of MSCs during tissue regeneration and therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI