材料科学
电极
纳米技术
涂层
生物相容性
电活性聚合物
聚合物
导电聚合物
生物电子学
表面改性
电极阵列
生物医学工程
生物传感器
复合材料
机械工程
物理化学
工程类
化学
冶金
医学
作者
Jiajun Zhang,Lulu Wang,Yu Xue,Iek Man Lei,Xingmei Chen,Pei Zhang,Chengcheng Cai,Xiangyu Liang,Yi Lu,Ji Liu
标识
DOI:10.1002/adma.202209324
摘要
Coating conventional metallic electrodes with conducting polymers has enabled the essential characteristics required for bioelectronics, such as biocompatibility, electrical conductivity, mechanical compliance, and the capacity for structural and chemical functionalization of the bioelectrodes. However, the fragile interface between the conducting polymer and the electrode in wet physiological environment greatly limits their utility and reliability. Here, a general yet reliable strategy to seamlessly interface conventional electrodes with conducting hydrogel coatings is established, featuring tissue-like modulus, highly-desirable electrochemical properties, robust interface, and long-term reliability. Numerical modeling reveals the role of toughening mechanism, synergy of covalent anchorage of long-chain polymers, and chemical cross-linking, in improving the long-term robustness of the interface. Through in vivo implantation in freely-moving mouse models, it is shown that stable electrophysiological recording can be achieved, while the conducting hydrogel-electrode interface remains robust during the long-term low-voltage electrical stimulation. This simple yet versatile design strategy addresses the long-standing technical challenges in functional bioelectrode engineering, and opens up new avenues for the next-generation diagnostic brain-machine interfaces.
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