肥大细胞
疾病
药品
医学
药物输送
靶向给药
细胞
计算生物学
免疫学
生物
药理学
纳米技术
病理
遗传学
材料科学
作者
Clayton H. Rische,Ariel Helms Thames,Rebecca A. Krier-Burris,Jeremy A. O’Sullivan,Bruce S. Bochner,Evan A. Scott
标识
DOI:10.1080/17425247.2023.2166926
摘要
Current and developing mast cell therapeutics are reliant on small molecule drugs and biologics, but few are truly selective for mast cells. Most have cellular and disease-specific limitations that require innovation to overcome longstanding challenges to selectively targeting and modulating mast cell behavior. This review is designed to serve as a frame of reference for new approaches that utilize nanotechnology or combine different drugs to increase mast cell selectivity and therapeutic efficacy.Mast cell diseases include allergy and related conditions as well as malignancies. Here, we discuss the targets of existing and developing therapies used to treat these disease pathologies, classifying them into cell surface, intracellular, and extracellular categories. For each target discussed, we discuss drugs that are either the current standard of care, under development, or have indications for potential use. Finally, we discuss how novel technologies and tools can be used to take existing therapeutics to a new level of selectivity and potency against mast cells.There are many broadly and very few selectively targeted therapeutics for mast cells in allergy and malignant disease. Combining existing targeting strategies with technology like nanoparticles will provide novel platforms to treat mast cell disease more selectively.
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