光动力疗法
聚集诱导发射
亮度
材料科学
分辨率(逻辑)
纳米技术
光化学
光学
化学
荧光
光电子学
物理
计算机科学
有机化学
人工智能
作者
Zhi Wang,Yu Zhou,Ying Hao,Zhiqin Zhao,Anran Gao,Haoxin Ma,Peijuan Zhang,Qifei Shen,Ruohan Xu,Yanzi Xu,Dongfeng Dang,Lingjie Meng
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-02-28
标识
DOI:10.1021/acs.nanolett.3c04099
摘要
Most aggregation-induced emission (AIE) luminogens exhibit high brightness, excellent photostability, and good biocompatibility, but these AIE-active agents, which kill two birds with one stone to result in applications in both stimulated emission depletion (STED) super-resolution imaging and photodynamic therapy (PDT), have not been reported yet but are urgently needed. To meet the requirements of STED nanoscopy and PDT, D-A-π-A-D type DTPABT-HP is designed by tuning conjugated π spacers. It exhibits red-shifted emission, high PLQY of 32.04%, and impressive 1O2 generation (9.24 fold compared to RB) in nanoparticles (NPs). Then, DTPABT-HP NPs are applied in cell imaging via STED nanoscopy, especially visualizing the dynamic changes of lysosomes in the PDT process at ultrahigh resolution. After that, in vivo PDT was also conducted by DTPABT-HP NPs, resulting in significantly inhibited tumor growth, with an inhibition rate of 86%. The work here is beneficial to the design of multifunctional agents and the deep understanding of their phototheranostic mechanism in biological research.
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