化学
氧化酶试验
脱氢
NAD+激酶
氮氧化物
烟酰胺腺嘌呤二核苷酸
组合化学
纳米技术
生物物理学
催化作用
生物化学
酶
材料科学
生物
燃烧
有机化学
作者
Shaomin Liu,Bin Yu,Mingjie Rong,Wenbo Sun,Lehui Lu
出处
期刊:Nano Today
[Elsevier]
日期:2024-02-01
卷期号:54: 102113-102113
标识
DOI:10.1016/j.nantod.2023.102113
摘要
Constructing robust enzyme mimics capable of disrupting cellular nicotinamide adenine dinucleotide (NAD) homeostasis, such as NADH oxidase (NOX) nanozymes, is emerging as a novel and powerful means to treat cancer. However, owing to the tumor heterogeneity, NOX nanozymes exhibit the different sensitivities toward hypoxic and normoxic cancer cells inside solid tumors, which pose a severe barrier for achieving high therapeutic efficacy. Herein, we propose an innovative design strategy of NOX nanozymes to simultaneously improve the two half-reactions related to NADH oxidation via metal-defect engineering. Taking advantages of distinctive electronic configuration and deprotonation effect around Cu-defect active sites, Cu2−xSe nanozymes perform excellent NADH dehydrogenation activity and preferential 4e- oxygen reduction selectivity, thus decreasing the requirement of O2 in heterogeneous tumor microenvironment. Such unique NADH consumption action of Cu2−xSe nanozymes efficiently disrupts metabolic networks of solid tumor and enables enhanced antitumor efficacy, which provides a new insight on the constructing metal-defect active centers in NOX nanozymes.
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