代谢组学
妊娠期糖尿病
糖尿病
半胱氨酸
仿形(计算机编程)
内科学
生物信息学
内分泌学
生物
计算生物学
医学
遗传学
生物化学
怀孕
妊娠期
酶
计算机科学
操作系统
作者
Mengyu Lai,Jiaomeng Li,Jing Yang,Qingli Zhang,Yujia Gong,Yuhang Ma,Fang Fang,Na Li,Yingxiang Zhai,Tingting Shen,Yongde Peng,Jia Liu,Yufan Wang
摘要
Abstract Gestational diabetes mellitus (GDM) is a pregnancy-related metabolic disorder associated with short-term and long-term adverse health outcomes, but its pathogenesis has not been clearly elucidated. Investigations of the dynamic changes in metabolomic markers in different trimesters may reveal the underlying pathophysiology of GDM progression. Therefore, in the present study, we analyzed the metabolic profiles of 75 women with GDM and 75 women with normal glucose tolerance (NGT) throughout the three trimesters. We found that the variation trends of 38 metabolites were significantly different during GDM development. Specifically, longitudinal analyses revealed that cysteine (Cys) levels significantly decreased over the course of GDM progression. Further study showed that Cys alleviated GDM in female mice at gestational day 14.5 possibly by inhibiting phosphoenolpyruvate carboxykinase to suppress hepatic gluconeogenesis. Taken together, these findings suggest that the Cys metabolic pathway might play a crucial role in GDM and that Cys supplementation represents a potential new treatment strategy for GDM patients.
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