Bimetallic Cobalt Copper Organic Framework Integrating Multi-Wall Carbon Nanotubes and Gold Nanoparticles for Glucose Sensor

Bimetallic metal-organic framework (CuCo-BTC) was synthesized via a facile hydrothermal method and then CuCo-BTC/Au/multi-wall carbon nanotubes (MWCNTs) composite was prepared on copper foam (CuCo-BTC/Au/MWCNTs/CF) for glucose sensing. Due to the synergistic effect of bimetal active sites, the excellent conductivity and large surface area of MWCNTs, and the good catalytic activity of gold, CuCo-BTC/Au/MWCNTs/CF had increased active sites, enhanced charge transfer and improved electro-catalytic performance. As a result, under optimized conditions, the electrode exhibited a wide linear range of 0.01–5 mM, 5–9 mM, a sensitivity of 1.029 mA mM −1 cm −2 , and a detection limit of 3.4 μ M (S/N = 3) for glucose detection. Meanwhile, it demonstrated satisfactory selectivity, reproducibility and stability. Furthermore, the electrode was successfully applied for the detection of glucose in serum. This work validates the potential of the fabricated sensor for non-enzymatic blood glucose monitoring.