红树林
立体化学
环己烯
化学
真菌
圆二色性
绝对构型
二维核磁共振波谱
曲霉
红茄苳
细胞毒性T细胞
生物
微生物学
植物
有机化学
生物化学
体外
生态学
催化作用
作者
Xianglong Bo,Yufei Zhao,Qicheng Feng,Fang Wu,Meijing Tan,S. Q. Ju,Zhiguo J. Song,Wenjun Li,Fan He,Youquan Wei,Hengyong Xu,Xishan Huang
标识
DOI:10.1080/14786419.2024.2303601
摘要
A new benzoquinone, guxiumasperone A (1), and a new diisoprenyl-cyclohexene-type meroterpenoids, biscognienyne M (2), along with four known diisoprenyl-cyclohexene analogues was isolated from the mangrove endophytic fungus Aspergillus QG1a. Their structures were determined by extensive spectral analysis of 1D and 2D NMR, HR-ESI- MS, and X-ray crystallography. Compound 1 was deduced by a single-crystal X-ray diffraction analysis, and the absolute configuration of 2 was further unequivocally elucidated by comparing the experimental electronic circular dichroism (ECD) data with calculated ECD spectra. Compounds 1 and 2 showed significant cytotoxic activity against selected tumour cells. Particularly, compound 2 exhibited strong activity against A2780 cancer cells with an IC50 value of 6.8 μM.
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