Phytochemical Characterization, Prooxidant, Antiproliferative and Anti‐Inflammatory Potential of Meyna spinosa Roxb. Ex Link Ripe Fruit

of 7.5 µg/mL), while the M. spinosa methanolic extract (MSM) exhibited higher FRAP activity (39.666 µg AAE/g DW). Prooxidant activity was demonstrated through Trolox and NADH oxidation. Both extracts exhibited antiproliferative effects in A549 and MCF7 cancer cells with an increase in concentration and time. Anti-inflammatory effects were observed by reductions in nitric oxide, COX-2, IL-6 and TNF-α levels in lipopolysaccharides-stimulated RAW 264.7 and THP-1 cells. Nitrite levels reduced from 23.778 to 5.222 µM, COX-2 levels from 51.136 to 9.581 µg/mL, IL-6 levels from 62.728 ng/mL to 13.463 pg/mL and TNF-α level from 474.890 to 143.115 pg/mL. In vivo, MSEA reduced carrageenan-induced paw oedema by 23.45%.