化学
糖基化
组合化学
反应条件
生物化学
立体化学
催化作用
作者
Jiaojiao Shen,Gongming Zhu,Yanbo You,Bianbian Huo,Fangyin Dai,Honglei Wang,Anlian Zhu,Lingjun Li
标识
DOI:10.1021/acs.orglett.3c01391
摘要
Modifications on the hydroxyl groups of ADP-ribosyl units can provide valuable tools for investigating ADP-ribosylation-related molecular interactions, but the chemical syntheses of these compounds are usually difficult due to their inherent complex structures. In this study, we report a poststage synthetic protocol for accessing novel ADP-2″-deoxyribosyl derivatives through designing a light-induced biomimetic reaction, and SPR assays revealed effective binding of ADP-2″-deoxyribosyl peptides to MacroH2A1.1 with a high affinity (KD = 3.75 × 10-6 M).
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