生物
病毒学
2019年冠状病毒病(COVID-19)
病毒
2019-20冠状病毒爆发
联想(心理学)
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
倍他科诺病毒
大流行
遗传学
爆发
疾病
传染病(医学专业)
医学
病理
哲学
认识论
作者
Na Zhang,Yujing Chen,Chune Li,Xiaoyue Qin,Dan He,Wenming Wei,Yijing Zhao,Qingqing Cai,Sirong Shi,Xiaoge Chu,Yan Wen,Yumeng Jia,Feng Zhang
标识
DOI:10.1016/j.micinf.2023.105170
摘要
Previous studies identified a number of diseases were associated with 2019 coronavirus disease (COVID-19). However, the associations between these diseases related viral infections and COVID-19 remains unknown now.In this study, we utilized single nucleotide polymorphisms (SNPs) related to COVID-19 from genome-wide association study (GWAS) and individual-level genotype data from the UK biobank to calculate polygenic risk scores (PRS) of 487,409 subjects for eight COVID-19 clinical phenotypes. Then, multiple logistic regression models were established to assess the correlation between serological measurements (positive/negative) of 25 viruses and the PRS of eight COVID-19 clinical phenotypes. And we performed stratified analyses by age and gender.In whole population, we identified 12 viruses associated with the PRS of COVID-19 clinical phenotypes, such as VZV seropositivity for Varicella Zoster Virus (Unscreened/Exposed_Negative: β = 0.1361, P = 0.0142; Hospitalized/Unscreened: β = 0.1167, P = 0.0385) and MCV seropositivity for Merkel Cell Polyomavirus (Unscreened/Exposed_Negative: β = -0.0614, P = 0.0478). After age stratification, we identified seven viruses associated with the PRS of eight COVID-19 clinical phenotypes in the age < 65 years group. After gender stratification, we identified five viruses associated with the PRS of eight COVID-19 clinical phenotypes in the women group.Our study findings suggest that the genetic susceptibility to different COVID-19 clinical phenotypes is associated with the infection status of various common viruses.
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