Distillers' grains (DGs) are industrial byproducts generated during the production of grain spirits, and their large-scale accumulation can easily lead to severe environmental pollution problems. This study provides the first comprehensive bibliometric analysis of DG-related publications from January 1940 to July 2025. The evolution of global research on DGs can be divided into four distinct stages: the initial stage (1940-1990), the emergence stage (1991-2003), the development stage (2004-2009), and the in-depth development stage (2010-2025). The results reveal that active research countries, institutions, and authors are concentrated mainly in Europe, North America, and Asia, with the United States, China, and Canada emerging as major contributors to DGs research. In particular, the United States and Canada have taken the lead in studies on the utilization of DGs. In terms of research topics, environmental issues caused by the accumulation of DGs have received increasing attention in recent years, especially in China. Current hotspots focus mainly on DGs as animal feed, including their effects on livestock health and product quality. By analysing research hotspots, trends and directions, it is expected that research on high-value utilization or deep processing of DGs by chemical methods will gradually become a popular field in the future and will become the main direction of DGs research. At present, the comprehensive utilization of DGs faces challenges such as unstable raw materials, high technical difficulty in comprehensive utilization, low economic benefits, and an incomplete evaluation standard; future efforts should therefore prioritize targeted technological innovation and fundamental research to overcome these bottlenecks. This study can provide researchers with insights for selecting topics and finding suitable research directions and can also serve as a reference for government departments in formulating plans and making funding decisions related to DGs waste management.