Cancer-associated fibroblast exosomal miR-214-3p regulated by hnRNPA2B1 promotes cisplatin resistance by inhibiting ferroptosis

Collectively, our findings elucidated a novel mechanism by which hnRNPA2B1 governed exosomal miRNA sorting in CAF and highlight the CAF exosomal miR-214-3p/GPX4 axis as a key mediator of ferroptosis evasion and cisplatin resistance in osteosarcoma. Targeting exosome-mediated communication within the tumor microenvironment may offer promising therapeutic approaches for overcoming chemotherapy resistance.