肿瘤微环境
新陈代谢
氨基酸
生物
运输机
生物化学
谷氨酸受体
胞饮病
化学
细胞生物学
细胞
肿瘤细胞
癌症研究
基因
受体
内吞作用
作者
Julian Wong Soon,Maria Antonietta Manca,Agnieszka Laskowska,Júlia Starková,Kateřina Rohlenová,Jakub Rohlena
标识
DOI:10.1016/j.bbadis.2024.167451
摘要
Aspartate is a proteinogenic non-essential amino acid with several essential functions in proliferating cells. It is mostly produced in a cell autonomous manner from oxalacetate via glutamate oxalacetate transaminases 1 or 2 (GOT1 or GOT2), but in some cases it can also be salvaged from the microenvironment via transporters such as SLC1A3 or by macropinocytosis. In this review we provide an overview of biosynthetic pathways that produce aspartate endogenously during proliferation. We discuss conditions that favor aspartate uptake as well as possible sources of exogenous aspartate in the microenvironment of tumors and bone marrow, where most available data have been generated. We highlight metabolic fates of aspartate, its various functions, and possible approaches to target aspartate metabolism for cancer therapy.
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