Electrochemical Synthesis of CuO Nano Flowers Supported on Reduced Graphene Oxide and Its Application as Glucose Sensor

Abstract A novel nonenzymatic glucose sensor based on a CuO nanoflowers‐decorated reduced graphene oxide (CuONFs@rGO) nanocomposite was successfully fabricated via a facile, green, and cost‐effective electrochemical anodization method. In this synthesis, NaOH served both as the electrolyte and reducing agent, enabling the efficient deposition of CuO nanoflowers onto rGO sheets through electrochemical etching.The structural and morphological characteristics of the CuONFs@rGO nanocomposite were thoroughly investigated using high‐resolution transmission electron microscopy (HR‐TEM), field emission scanning electron microscopy (FE‐SEM), X‐ray diffraction (XRD), and electrochemical impedance spectroscopy (EIS). Electrochemical performance was evaluated using cyclic voltammetry and chronoamperometry techniques.The CuONFs@rGO‐modified electrode exhibited outstanding electrocatalytic activity toward glucose oxidation in alkaline media, with a significant reduction in overpotential compared to previously reported systems. The sensor demonstrated high sensitivity (2294.33 µA·mM −1 ·cm −2 ), a low detection limit (0.9 µM, S/N = 3), and a wide linear detection range (0.01–3 mM). Additionally, the sensor showed excellent selectivity, reproducibility, and stability, confirming its potential for practical applications in nonenzymatic glucose sensing.