化学
分子内力
产量(工程)
芳基
键裂
药物化学
氧气
光化学
有机化学
催化作用
烷基
材料科学
冶金
作者
Xue Li,Lixin Liao,Linglong Ding,Chunhua Chen,Cui Liang,Dong‐Liang Mo
标识
DOI:10.1021/acs.orglett.4c00693
摘要
We described an iron(III) and BF3·OEt2-promoted oxygen transfer reaction of N-aryl-α,β-unsaturated nitrones to prepare various N,O-difluoroboron β-ketoiminates in good yields ranging from 24% to 87%. Control experiments revealed that the enaminone was the vital intermediate for the formation of N,O-difluoroboron β-ketoiminates, and iron(III) combined with BF3·OEt2 played as cocatalyst to promote the oxygen transfer reaction through intramolecular cyclization and N-O bond cleavage. More importantly, an estrone-derived N,O-difluoroboron β-ketoiminate was easily prepared in 40% yield from estrone in four steps.
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