光动力疗法
光敏剂
活性氧
药物发现
化学
纳米技术
光化学
材料科学
生物化学
有机化学
作者
Qicai Xiao,Juan Wu,Xin Pang,Yue Jiang,Pan Wang,Alexander K C Leung,Liqian Gao,Sheng Jiang,Chuanshan Xu
标识
DOI:10.2174/0929867324666170823143137
摘要
Photodynamic therapy (PDT) has been developed as an alternative modality for the management of neoplastic and nonneoplastic diseases. It is a minimally invasive treatment that involves the interaction of a non-toxic photosensitizer (PS), light and molecular oxygen to generate reactive oxygen species (ROS), resulting in the destruction of unwanted cells and tissues. Discovery and development of new PSs with optimized properties are much crucial for achieving a desirable therapeutic efficacy. This review describes the photochemical and photobiological mechanisms of PDT, and outlines the recent progress in discovery and development of natural products and their derivatives as phototherapeutic drugs. The potential limitations and future perspectives of PDT in clinical application are also presented and discussed.
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